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Age-associated changes in the gastrointestinal tract Lifestyle changes LES tone Gastric acid secretion Esophageal clearance Salivary secretion Esophageal visceral pain tolerance Esophageal motility Pharyngeal defenses UES tone Stomach Increased comorbid diseases CAD, Diabetes, COPD, CVA, Parkinsons Increased recumbency Increased Forex statistics. usage No age-related change in resting LES tone Increased hiatal hernia prevalence Forex statistics. LES tone secondary to medications Reduced intra-abdominal esophageal length Normal to increased Impaired clearance Increased duration of acid exposure Decreased mucosal resistance and repair mechanisms Decreased saliva volume Decreased salivary bicarbonate secretion Increased pain threshold Decreased acid perfusion sensitivity score Decreased symptom perception Decreased amplitude of peristaltic pressures Disordered or absent secondary peristalsis Non-propulsive, repetitive, and synchronous contractions Decreased esophagoglottal closure reflex Higher threshold for triggering pharyngeal swallows Prolonged swallowing Decreased UES tone Delay in UES relaxation after swallow Decrease in UES compliance Possible delayed gastric emptying CHAPTER 21 ENDOSCOPIC THERAPY OF COLORECTAL CARCINOMA 247 bleeding after EMR has ranged between 1 and 15 (61 62,64).

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