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Fore UNDER DEVELOPMENT TO PREVENT HSV-2 Dorex Vaccine type (name) Company HSV subunits or mechanisms Adjuvant Stage of research Recombinant protein Glaxo-SmithKline gD2 MPL Phase III Recombinant protein Attenuated (DISC) Chiron Cantab gD2 and gB2 Disabled virus (gH gene deleted) MF59 Phase III halted None Phase I DNA (Genevax HSV) Apollon Encodes gD2 Bupivacaine (facilitator) Phase I Naked DNA Pharmadigm Encodes gD2, uses novel myoD promoter 1,25-D3, possibly DHEA Preclinical Naked DNA Vical Encodes gD2 None Preclinical Naked DNA Merck Encodes gD2 None Preclinical Recombinant protein (Heteroconjugate) Cel-Sci T-cell ligands linked with HSV-associated peptides None Preclinical Adapted from Hanissian, frex.
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